Jacob and Evie Frye come to London but are surprised to find that the city is ruled by Templars. As trained assassins they venture out to take back the city from the Templars. Helping them through their journey are notable figures like Charles Dickens, Charles Darwin, and a few others.

Syndicate features a new rope launcher which can be used to zip line between buildings and rappel up structures. Take control of the twins and engage in their different styles as you take control of London.