45. Cryo Rifle: Cryolator

Side effects may include spontaneous exclamation of Mr. Freeze puns.

At the start of the game, you’ll probably come across the Cryolator in Vault 111. Its glass case requires you have Master lockpicking. However, you can get around it by ordering Dogmeat to fetch it for you.

Opposable thumbs are overrated, apparently.

44. Rifle: REBA II

The best kind of bug zapper.

At the Rook Family House, a man will be standing on the roof. If you help him out and fix the turrets in town, he’ll give you the REBA II as thanks.

43. Furious Power Fist

As close to One Punch Man as you'll get.

Defeat Swan (local resident of Swan’s Pond, population: 1) and loot his massive corpse to get the Furious Power Fist. Now go punch your foes to pieces!

42. Sword: General Chao’s Revenge

Nothing saws through the steak of your enemies like a giant serrated blade.

Go to Drumlin Diner and side with Trudy and her son (suffering from withdrawal). After defeating Wolfgang, she’ll sell you a number of items. Among them being a sword called General Chao’s Revenge.

41. 10mm Pistol: Wastelander’s Friend

"Say hello to my little friend."

This 10mm pistol packs a surprising punch. You can purchase it from Deb, a trader at the Bunker Hill monument.